Association of lung function with cognitive decline and dementia: the Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Background

Previous studies reported a higher risk of cognitive decline and dementia amongst individuals with impaired lung function. However, many did not adjust for important confounders or did not include women and non-whites.

Methods

We studied 10,975 men and women aged 47-70 years (23% African-Americans) enrolled in the Atherosclerosis Risk in Communities Study. Pulmonary function tests and a cognitive assessment, including the Delayed Word Recall, the Digit Symbol Substitution, and the World Fluency Tests, were carried out in 1990-1992. Repeated cognitive assessments were performed in 1996-1998 for the entire cohort, and in 1993-1995, and 2004-2006 in 904 eligible individuals. Dementia hospitalization was ascertained through 2005.

Results

In analysis adjusted fo

SUBMITTER: Pathan SS 

PROVIDER: S-EPMC3092022 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature