Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned.

ABSTRACT: Candidate gene association studies, linkage studies and genome-wide association studies have highlighted the role of genetic factors in the development of ischemic stroke. This research started over a decade ago, and can be separated into three major periods of research. In the first wave classic susceptibility markers associated with other diseases (such as the Leiden mutation in Factor V and mutations in the prothrombin and 5,10-methylenetetrahydrofolate reductase (MTHFR) genes) were tested for their role in stroke. These first studies used just a couple of hundred samples or even less. The second and still ongoing period bridges the two other periods of research and has led to a rapid increase in the spectrum of functional variants of genes or genomic regions, discovered primarily in re

SUBMITTER: Maasz A 

PROVIDER: S-EPMC3092115 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature