A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostate Cancer Cells.

ABSTRACT: Drug resistance remains a clinical challenge in cancer treatment due to poor understanding of underlying mechanisms. We have established several drug-resistant prostate cancer cell lines by long-term culture in medium containing chemotherapeutic drugs. These resistant lines displayed a significant increase in side population cells due to overexpression of drug efflux pumps including ABCG2/BCRP and MDR1/Pgp. To uncover potential mechanisms underlying drug resistance, we performed microarray analysis to identify differentially expressed genes in 2 drug-resistant lines. We observed that POU5F1/OCT4, a transcription factor key to regulating pluripotency in embryonic stem cells, was upregulated in drug-resistant lines and accompanied by transcriptional activation of a set of its known target ge

SUBMITTER: Linn DE 

PROVIDER: S-EPMC3092260 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature