Identification of the YES1 Kinase as a Therapeutic Target in Basal-Like Breast Cancers.

ABSTRACT: Normal cellular behavior can be described as a complex, regulated network of interaction between genes and proteins. Targeted cancer therapies aim to neutralize specific proteins that are necessary for the cancer cell to remain viable in vivo. Ideally, the proteins targeted should be such that their downregulation has a major impact on the survival/fitness of the tumor cells and, at the same time, has a smaller effect on normal cells. It is difficult to use standard analysis methods on gene or protein expression levels to identify these targets because the level thresholds for tumorigenic behavior are different for different genes/proteins. We have developed a novel methodology to identify therapeutic targets by using a new paradigm called "gene centrality." The main idea is that, in addit

SUBMITTER: Bilal E 

PROVIDER: S-EPMC3092264 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature