Hepatic gene expression profiling of 5'-AMP-induced hypometabolism in mice.

ABSTRACT: There is currently much interest in clinical applications of therapeutic hypothermia. Hypothermia can be a consequence of hypometabolism. We have recently established a procedure for the induction of a reversible deep hypometabolic state in mice using 5'-adenosine monophosphate (5'-AMP) in conjunction with moderate ambient temperature. The current study aims at investigating the impact of this technology at the gene expression level in a major metabolic organ, the liver. Our findings reveal that expression levels of the majority of genes in liver are not significantly altered by deep hypometabolism. However, among those affected by hypometabolism, more genes are differentially upregulated than downregulated both in a deep hypometabolic state and in the early arousal state. These altered ge

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC3092333 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature