Identification of maternally regulated fetal gene networks in the placenta with a novel embryo transfer system in mice.

ABSTRACT: The mechanisms for provisioning maternal resources to offspring in placental mammals involve complex interactions between maternally regulated and fetally regulated gene networks in the placenta, a tissue that is derived from the zygote and therefore of fetal origin. Here we describe a novel use of an embryo transfer system in mice to identify gene networks in the placenta that are regulated by the mother. Mouse embryos from the same strain of inbred mice were transferred into a surrogate mother either of the same strain or from a different strain, allowing maternal and fetal effects on the placenta to be separated. After correction for sex and litter size, maternal strain overrode fetal strain as the key determinant of fetal weight (P < 0.0001). Computational filtering of the placental tr

SUBMITTER: SenthamaraiKannan P 

PROVIDER: S-EPMC3092334 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature