Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women.

ABSTRACT: Growth hormone is one of few pharmacologic agents known to augment milk production in humans. We hypothesized that recombinant human GH (rhGH) increases the expression of cell proliferation and milk protein synthesis genes. Sequential milk and blood samples collected over four days were obtained from five normal lactating women. Following 24 h of baseline milk and blood sampling, rhGH (0.1 mg/kg/day) was administered subcutaneously once daily for 3 days. Gene expression changes were determined by microarray studies utilizing milk fat globule RNA isolated from each milk sample. Following rhGH administration, DNA synthesis and cell cycle genes were induced, while no significant changes were observed in the expression of milk synthesis genes. Expression of glycolysis and citric acid cycle gen

SUBMITTER: Maningat PD 

PROVIDER: S-EPMC3092339 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature