Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study.

ABSTRACT:

Objective

To examine the effect of proton pump inhibitors on adverse cardiovascular events in aspirin treated patients with first time myocardial infarction.

Design

Retrospective nationwide propensity score matched study based on administrative data. Setting All hospitals in Denmark.

Participants

All aspirin treated patients surviving 30 days after a first myocardial infarction from 1997 to 2006, with follow-up for one year. Patients treated with clopidogrel were excluded.

Main outcome measures

The risk of the combined end point of cardiovascular death, myocardial infarction, or stroke associated with use of proton pump inhibitors was analysed using Kaplan-Meier analysis, Cox proportional hazard models, and propensity score matched Cox proportional hazard model

SUBMITTER: Charlot M 

PROVIDER: S-EPMC3092520 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature