Quantitative subcellular proteome and secretome profiling of influenza A virus-infected human primary macrophages.

ABSTRACT: Influenza A viruses are important pathogens that cause acute respiratory diseases and annual epidemics in humans. Macrophages recognize influenza A virus infection with their pattern recognition receptors, and are involved in the activation of proper innate immune response. Here, we have used high-throughput subcellular proteomics combined with bioinformatics to provide a global view of host cellular events that are activated in response to influenza A virus infection in human primary macrophages. We show that viral infection regulates the expression and/or subcellular localization of more than one thousand host proteins at early phases of infection. Our data reveals that there are dramatic changes in mitochondrial and nuclear proteomes in response to infection. We show that a rapid cytopl

SUBMITTER: Lietzen N 

PROVIDER: S-EPMC3093355 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature