Neuroanatomical profiles of personality change in frontotemporal lobar degeneration.

ABSTRACT:

Background

The neurobiological basis of personality is poorly understood. Frontotemporal lobar degeneration (FTLD) frequently presents with complex behavioural changes, and therefore potentially provides a disease model in which to investigate brain substrates of personality.

Aims

To assess neuroanatomical correlates of personality change in a cohort of individuals with FTLD using voxel-based morphometry (VBM).

Method

Thirty consecutive individuals fulfilling consensus criteria for FTLD were assessed. Each participant's carer completed a Big Five Inventory (BFI) questionnaire on five key personality traits; for each trait, a change score was derived based on current compared with estimated premorbid characteristics. All participants underwent volumetric brain magnetic

SUBMITTER: Mahoney CJ 

PROVIDER: S-EPMC3093679 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature