Genomic instability in human actinic keratosis and squamous cell carcinoma.

ABSTRACT:

Objective

To compare the repetitive DNA patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation.

Introduction

Cancer cells are prone to genomic instability, which is often due to DNA polymerase slippage during the replication of repetitive DNA and to mutations in the DNA repair genes. The progression of benign actinic keratoses to malignant squamous cell carcinomas has been proposed by several authors.

Material and methods

Eight actinic keratoses and 24 squamous cell carcinomas (SCC), which were pair-matched to adjacent skin tissues and/or leucocytes, were studied. The presence of microsatellite instability (MSI) and the loss of heterozygosity (LOH) in chromosomes 6 and 9 w

SUBMITTER: Cabral LS 

PROVIDER: S-EPMC3093780 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature