Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions.

ABSTRACT: Membrane proteins and membrane lipids are frequently organized in submicron-sized domains within cellular membranes. Factors thought to be responsible for domain formation include lipid-lipid interactions, lipid-protein interactions and protein-protein interactions. However, it is unclear whether the domain structure is regulated by other factors such as divalent cations. Here, we have examined in native plasma membranes and intact cells the role of the second messenger Ca(2+) in membrane protein organization. We find that Ca(2+) at low micromolar concentrations directly redistributes a structurally diverse array of membrane proteins via electrostatic effects. Redistribution results in a more clustered pattern, can be rapid and triggered by Ca(2+) influx through voltage-gated calcium chann

SUBMITTER: Zilly FE 

PROVIDER: S-EPMC3094119 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature