Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis.

ABSTRACT: It has long been known that mammalian enterocytes coexpress two members of the fatty acid-binding protein (FABP) family, the intestinal FABP (IFABP) and the liver FABP (LFABP). Both bind long-chain fatty acids and have similar though not identical distributions in the intestinal tract. While a number of in vitro properties suggest the potential for different functions, the underlying reasons for expression of both proteins in the same cells are not known. Utilizing mice genetically lacking either IFABP or LFABP, we directly demonstrate that each of the enterocyte FABPs participates in specific pathways of intestinal lipid metabolism. In particular, LFABP appears to target fatty acids toward oxidative pathways and dietary monoacylglycerols toward anabolic pathways, while IFABP targets dieta

SUBMITTER: Lagakos WS 

PROVIDER: S-EPMC3094135 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature