A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress.

ABSTRACT:

Background

In aerobically grown cells, iron homeostasis and oxidative stress are tightly linked processes implicated in a growing number of diseases. The deregulation of iron homeostasis due to gene defects or environmental stresses leads to a wide range of diseases with consequences for cellular metabolism that remain poorly understood. The modelling of iron homeostasis in relation to the main features of metabolism, energy production and oxidative stress may provide new clues to the ways in which changes in biological processes in a normal cell lead to disease.

Results

Using a methodology based on probabilistic Boolean modelling, we constructed the first model of yeast iron homeostasis including oxygen-related reactions in the frame of central metabolism. The resulting mod

SUBMITTER: Achcar F 

PROVIDER: S-EPMC3094212 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature