Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization.

ABSTRACT:

Background

Optimizing treatment through microarray-based molecular subtyping is a promising method to address the problem of heterogeneity in breast cancer; however, current application is restricted to prediction of distant recurrence risk. This study investigated whether breast cancer molecular subtyping according to its global intrinsic biology could be used for treatment customization.

Methods

Gene expression profiling was conducted on fresh frozen breast cancer tissue collected from 327 patients in conjunction with thoroughly documented clinical data. A method of molecular subtyping based on 783 probe-sets was established and validated. Statistical analysis was performed to correlate molecular subtypes with survival outcome and adjuvant chemotherapy regimens. Heterogene

SUBMITTER: Kao KJ 

PROVIDER: S-EPMC3094326 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature