Admixture mapping to identify spontaneous preterm birth susceptibility loci in African Americans.

ABSTRACT:

Objective

Preterm birth is 1.5 times more common in African American (17.8%) than European American women (11.5%), even after controlling for confounding variables. We hypothesize that genetic factors may account for this disparity and can be identified by admixture mapping.

Methods

This is a secondary analysis of women with at least one prior spontaneous preterm birth enrolled in a multicenter prospective study. DNA was extracted and whole-genome amplified from stored saliva samples. Self-identified African American patients were genotyped with a 1,509 single nucleotide polymorphism (SNP) commercially available admixture panel. A logarithm of odds locus-genome score of 1.5 or higher was considered suggestive and 2 or higher was considered significant for a disease locus.

SUBMITTER: Manuck TA 

PROVIDER: S-EPMC3094723 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature