Induction of CXCR3- and CCR5-associated chemokines during acute hepatitis C virus infection.

ABSTRACT:

Background & aims

Characterization of inflammatory mediators, such as chemokines, during acute hepatitis C virus (HCV) infection might shed some light on viral clearance mechanisms.

Methods

Plasma levels of CXCR3 (CXCL9-11)- and CCR5 (CCL3-4)-associated chemokines, ALT, and HCV RNA were measured in nine injection drug users (median 26 samples/patient) before and during 10 acute (eight primary and two secondary) HCV infections. Using functional data analysis, we estimated smooth long-term trends in chemokine expression levels to obtain the magnitude and timing of overall changes. Residuals were analyzed to characterize short-term fluctuations.

Results

CXCL9-11 induction began 38-53days and peaked 72-83days after virus acquisition. Increases in ALT levels followed a sim

SUBMITTER: Zeremski M 

PROVIDER: S-EPMC3094733 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature