Mechanisms of drug resistance in kinases.

ABSTRACT:

Introduction

because of their important roles in disease and excellent 'druggability', kinases have become the second largest drug target family. The great success of the BCR-ABL inhibitor imatinib in treating chronic myelogenous leukemia illustrates the high potential of kinase inhibitor (KI) therapeutics, but also unveils a major limitation: the development of drug resistance. This is a significant concern as KIs reach large patient populations for an expanding array of indications.

Areas covered

we provide an up-to-date understanding of the mechanisms through which KIs function and through which cells can become KI-resistant. We review current and future approaches to overcome KI resistance, focusing on currently approved KIs and KIs in clinical trials. We then discuss ap

SUBMITTER: Barouch-Bentov R 

PROVIDER: S-EPMC3095104 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature