Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants.

ABSTRACT:

Background

The orderly progression through mitosis is regulated by the Anaphase-Promoting Complex (APC), a large multiprotein E3 ubiquitin ligase that targets key cell-cycle regulators for destruction by the 26 S proteasome. The APC is composed of at least 11 subunits and associates with additional regulatory activators during mitosis and interphase cycles. Despite extensive research on APC and activator functions in the cell cycle, only a few components have been functionally characterized in plants.

Results

Here, we describe an in-depth search for APC subunits and activator genes in the Arabidopsis, rice and poplar genomes. Also, searches in other genomes that are not completely sequenced were performed. Phylogenetic analyses indicate that some APC subunits and activator g

SUBMITTER: Lima Mde F 

PROVIDER: S-EPMC3095333 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature