PEX11β induces peroxisomal gene expression and alters peroxisome number during early Xenopus laevis development.

ABSTRACT:

Background

Peroxisomes are organelles whose roles in fatty acid metabolism and reactive oxygen species elimination have contributed much attention in understanding their origin and biogenesis. Many studies have shown that de novo peroxisome biogenesis is an important regulatory process, while yeast studies suggest that total peroxisome numbers are in part regulated by proteins such as Pex11, which can facilitate the division of existing peroxisomes. Although de novo biogenesis and divisions are likely important mechanisms, the regulation of peroxisome numbers during embryonic development is poorly understood. Peroxisome number and function are particularly crucial in oviparous animals such as frogs where large embryonic yolk and fatty acid stores must be quickly metabolized, and re

SUBMITTER: Fox MA 

PROVIDER: S-EPMC3095563 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature