The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response.

ABSTRACT:

Background

The state of operational tolerance has been detected sporadically in some renal transplanted patients that stopped immunosuppressive drugs, demonstrating that allograft tolerance might exist in humans. Several years ago, a study by Brouard et al. identified a molecular signature of several genes that were significantly differentially expressed in the blood of such patients compared with patients with other clinical situations. The aim of the present study is to analyze the role of one of these molecules over-expressed in the blood of operationally tolerant patients, SMILE or TMTC3, a protein whose function is still unknown.

Methodology/principal findings

We first confirmed that SMILE mRNA is differentially expressed in the blood of operationally tolerant patients

SUBMITTER: Racape M 

PROVIDER: S-EPMC3095597 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature