Genetics and genomics of Sjogren's syndrome: research provides clues to pathogenesis and novel therapies.

ABSTRACT:

Purpose

Although the key inciting events that drive the progression from autoantibodies to clinical disease remain to be clarified, new light has been shed on the factors contributing to disease susceptibility and the role of genetic factors in determining Sjögren's syndrome (SS) disease phenotypes. The purpose of this article is to provide an update on the role of genetic markers in the susceptibility to and pathogenesis of SS. This article also discusses how genomic and proteomic technology can help in the design of specific therapeutics.

Key findings

Recent evidence suggests that inflammatory genes associated with interferon pathways, and specific regulatory genes that control the maturation and proliferation of B cells, contribute to the pathogenesis of SS. Both gene exp

SUBMITTER: Segal BM 

PROVIDER: S-EPMC3095716 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature