The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50.

ABSTRACT: The specific binding of transcription factors to cognate sequence elements is thought to be critical for the generation of specific gene expression programs. Members of the nuclear factor κB (NF-κB) and interferon (IFN) regulatory factor (IRF) transcription factor families bind to the κB site and the IFN response element (IRE), respectively, of target genes, and they are activated in macrophages after exposure to pathogens. However, how these factors produce pathogen-specific inflammatory and immune responses remains poorly understood. Combining top-down and bottom-up systems biology approaches, we have identified the NF-κB p50 homodimer as a regulator of IRF responses. Unbiased genome-wide expression and biochemical and structural analyses revealed that the p50 homodimer repressed a subse

SUBMITTER: Cheng CS 

PROVIDER: S-EPMC3096068 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature