Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing.

ABSTRACT: Understanding tissue stem cells behavior is a prerequisite for elucidating the mechanisms that govern their self-renewal and differentiation. Previously, we provided single cell lineage tracing and proliferation history data (based on H2B-GFP label dilution over time) in mouse hair follicles. We proposed a population deterministic model with symmetric stem cell fate decisions throughout life. Here we provide data suggesting that in hair follicle stem cells the self-renewing divisions within the niche (bulge) are symmetric with respect to localization of daughter cells near the basement membrane, an important niche component. In contrast, when cells migrate from the niche to the differentiating zone where they become short-lived progenitors, their daughter cells can orient themselves asymme

SUBMITTER: Zhang YV 

PROVIDER: S-EPMC3096686 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature