Diastereoselective synthesis of diketopiperazine bis-α,β-epoxides.

ABSTRACT: Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-α,β-epoxides via the oxidation of exocyclic olefins. Although six diastereomers may be formed by this approach, only one or two of them were observed.

SUBMITTER: Ando S 

PROVIDER: S-EPMC3096722 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature