A comparison of the Giardia lamblia trophozoite and cyst transcriptome using microarrays.

ABSTRACT:

Background

Compared with many protists, Giardia lamblia has a simple life cycle alternating between cyst and trophozoite. Most research on the molecular biology of Giardia parasites has focused on trophozoites and the processes of excystation and encystation, whereas cysts have attracted less interest. The striking morphological differences between the dormant cyst and the rapidly dividing and motile trophozoite implies profound changes in the metabolism as the parasite encysts in the host's intestine and excysts upon ingestion by a new host.

Results

To investigate the magnitude of the transcriptional changes occurring during the G. lamblia life cycle we compared the transcriptome of G. lamblia trophozoites and cysts using single-color oligonucleotide microarrays. Cysts were

SUBMITTER: Faghiri Z 

PROVIDER: S-EPMC3096902 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature