Regioselective hydroformylation of allylic alcohols.

ABSTRACT: A highly regioselective hydroformylation of allylic alcohols is reported toward the synthesis of β-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur. The application to trisubstituted olefins was also demonstrated, which yields a single diastereomer product consistent with a stereospecific addition of CO and hydrogen.

SUBMITTER: Lightburn TE 

PROVIDER: S-EPMC3096926 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature