Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer.

ABSTRACT:

Introduction

In breast cancer, gene expression analyses have defined five tumor subtypes (luminal A, luminal B, HER2-enriched, basal-like and claudin-low), each of which has unique biologic and prognostic features. Here, we comprehensively characterize the recently identified claudin-low tumor subtype.

Methods

The clinical, pathological and biological features of claudin-low tumors were compared to the other tumor subtypes using an updated human tumor database and multiple independent data sets. These main features of claudin-low tumors were also evaluated in a panel of breast cancer cell lines and genetically engineered mouse models.

Results

Claudin-low tumors are characterized by the low to absent expression of luminal differentiation markers, high enrichment for ep

SUBMITTER: Prat A 

PROVIDER: S-EPMC3096954 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature