Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.

ABSTRACT:

Introduction

T-cell lymphoma invasion and metastasis-inducing protein (Tiam1) is a Ras-related C3 botulinum toxin substrate (Rac)-specific guanine nucleotide exchange factor that was isolated based on its ability to induce a metastatic phenotype. In polarized migrating keratinocytes, Tiam1 is found at the leading edge where it cooperates with the Protease-activated receptor 1 (Par1) complex to establish front-rear polarity. Although a positive correlation has been observed between Tiam1 expression and tumor grade in a variety of human malignancies, including breast, its role in breast cancer cells has not yet been examined.

Methods

Tiam1 expression and Rac activity were examined in a panel of human breast cancer cell lines which exhibit different degrees of cell motility. Th

SUBMITTER: Adams HC 

PROVIDER: S-EPMC3096956 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature