Differential expression of 14-3-3 isoforms in human alcoholic brain.

ABSTRACT:

Background

Neuropathological damage as a result of chronic alcohol abuse often results in the impairment of cognitive function. The damage is particularly marked in the frontal cortex. The 14-3-3 protein family consists of 7 proteins, β, γ, ε, ζ, η, θ, and σ, encoded by 7 distinct genes. They are highly conserved molecular chaperones with roles in the regulation of metabolism, signal transduction, cell-cycle control, protein trafficking, and apoptosis. They may also play an important role in neurodegeneration in chronic alcoholism.

Methods

We used real-time PCR to measure the expression of 14-3-3 mRNA transcripts in both the dorsolateral prefrontal cortex and motor cortex of human brains obtained at autopsy.

Results

We found significantly lower 14-3-3β, γ, and θ expre

SUBMITTER: MacKay RK 

PROVIDER: S-EPMC3097257 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature