IntelliGO: a new vector-based semantic similarity measure including annotation origin.

ABSTRACT:

Background

The Gene Ontology (GO) is a well known controlled vocabulary describing the biological process, molecular function and cellular component aspects of gene annotation. It has become a widely used knowledge source in bioinformatics for annotating genes and measuring their semantic similarity. These measures generally involve the GO graph structure, the information content of GO aspects, or a combination of both. However, only a few of the semantic similarity measures described so far can handle GO annotations differently according to their origin (i.e. their evidence codes).

Results

We present here a new semantic similarity measure called IntelliGO which integrates several complementary properties in a novel vector space model. The coefficients associated with each G

SUBMITTER: Benabderrahmane S 

PROVIDER: S-EPMC3098105 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature