A computational framework for gene regulatory network inference that combines multiple methods and datasets.

ABSTRACT:

Background

Reverse engineering in systems biology entails inference of gene regulatory networks from observational data. This data typically include gene expression measurements of wild type and mutant cells in response to a given stimulus. It has been shown that when more than one type of experiment is used in the network inference process the accuracy is higher. Therefore the development of generally applicable and effective methodologies that embed multiple sources of information in a single computational framework is a worthwhile objective.

Results

This paper presents a new method for network inference, which uses multi-objective optimisation (MOO) to integrate multiple inference methods and experiments. We illustrate the potential of the methodology by combining ODE and

SUBMITTER: Gupta R 

PROVIDER: S-EPMC3098160 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature