Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone.

ABSTRACT:

Background

Traumatic brain injury (TBI) causes acute inflammatory responses that result in an enduring cascade of secondary neuronal loss and behavioral impairments. It has been reported that progesterone (PROG) can inhibit the increase of some inflammatory cytokines and inflammation-related factors induced by TBI. Toll-like receptors (TLRs) play a critical role in the induction and regulation of immune/inflammatory responses. Therefore, in the present study, we examined the genomic profiles of TLR-mediated pathways in traumatically injured brain and PROG's effects on these genes.

Methods

Bilateral cortical impact injury to the medial frontal cortex was induced in C57BL/6J mice. PROG was injected (i.p., 16 mg/kg body weight) at 1 and 6 h after surgery. Twenty-four hours post

SUBMITTER: Hua F 

PROVIDER: S-EPMC3098165 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature