Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements.

ABSTRACT:

Background

Clostridium botulinum strains can be divided into four physiological groups that are sufficiently diverged to be considered as separate species. Here we present the first complete genome of a C. botulinum strain from physiological group III, causing animal botulism. We also compare the sequence to three new draft genomes from the same physiological group.

Results

The 2.77 Mb chromosome was highly conserved between the isolates and also closely related to that of C. novyi. However, the sequence was very different from the human C. botulinum group genomes. Replication-directed translocations were rare and conservation of synteny was high. The largest difference between C. botulinum group III isolates occurred within their surprisingly large plasmidomes and in the pa

SUBMITTER: Skarin H 

PROVIDER: S-EPMC3098183 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature