Effect of anti-IgE therapy on food allergen specific T cell responses in eosinophil associated gastrointestinal disorders.

ABSTRACT:

Background

Anti-IgE therapy inhibits mast cell and basophil activation, blocks IgE binding to both FcεRI and CD23 and down regulates FcεRI expression by antigen (Ag) presenting cells (APCs). In addition to its classical role in immediate hypersensitivity, IgE has been shown in vitro to facilitate Ag presentation of allergens, whereby APC bound IgE preferentially takes up allergens for subsequent processing and presentation. The purpose of this study was to determine whether anti-IgE therapy, by blocking facilitated Ag presentation in vivo, attenuates allergen specific Th2 cell responses.

Methods

To test this hypothesis, food allergen specific T cell responses were examined during a 16-week clinical trial of omalizumab in nine subjects with eosinophilic gastroenteritis and fo

SUBMITTER: Foster B 

PROVIDER: S-EPMC3098204 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature