Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria.

ABSTRACT:

Background

The World Health Organization endorses the use of artemisinin-based combination therapy for treatment of acute uncomplicated falciparum malaria in the second and third trimesters of pregnancy. However, the effects of pregnancy on the pharmacokinetics of artemisinin derivatives, such as artesunate (AS), are poorly understood. In this analysis, the population pharmacokinetics of oral AS, and its active metabolite dihydroartemisinin (DHA), were studied in pregnant and non-pregnant women at the Kingasani Maternity Clinic in the DRC.

Methods

Data were obtained from 26 pregnant women in the second (22-26 weeks) or the third (32-36 weeks) trimester of pregnancy and from 25 non-pregnant female controls. All subjects received 200 mg AS. Plasma AS and DHA were measured usin

SUBMITTER: Morris CA 

PROVIDER: S-EPMC3098207 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature