Ontology highlight
ABSTRACT:
SUBMITTER: Kashiwada M
PROVIDER: S-EPMC3098483 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Kashiwada Masaki M Cassel Suzanne L SL Colgan John D JD Rothman Paul B PB
The EMBO journal 20110415 10
Type 2 T helper (T(H)2) cells are critical for the development of allergic immune responses; however, the molecular mechanism controlling their effector function is still largely unclear. Here, we report that the transcription factor NFIL3/E4BP4 regulates cytokine production and effector function by T(H)2 cells. NFIL3 is highly expressed in T(H)2 cells but much less in T(H)1 cells. Production of interleukin (IL)-13 and IL-5 is significantly increased in Nfil3(-/-) T(H)2 cells and is decreased by ...[more]