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Polymorphisms in interferon regulatory factor 7 reduce interferon-? responses of plasmacytoid dendritic cells to HIV-1.
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ABSTRACT:
SUBMITTER: Chang J
PROVIDER: S-EPMC3098498 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1.
AIDS (London, England) 20110301 5
Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-α (IFN-α), and the ability of plasmacytoid dendritic cells to produce IFN-α in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of indiv ...[more]