Shared gene expression alterations in schizophrenia and bipolar disorder.

ABSTRACT:

Background

Schizophrenia and bipolar disorder together affect approximately 2.5% of the world population, and their etiologies are thought to involve multiple genetic variants and environmental influences. The analysis of gene expression patterns in brain may provide a characteristic signature for each disorder.

Methods

RNA samples from the dorsolateral prefrontal cortex (Brodmann area 46) consisting of individuals with schizophrenia (SZ), bipolar disorder (BPD), and control subjects were tested on the Codelink Human 20K Bioarray platform. Selected transcripts were validated by quantitative real-time polymerase chain reaction (PCR). The strong effects of age, gender, and pH in the analysis of differential gene expression were controlled by analysis of covariance (ANCOVA). Cr

SUBMITTER: Shao L 

PROVIDER: S-EPMC3098561 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature