New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs.

ABSTRACT:

Background

Previously, in boars with extreme androstenone levels, differential expression of the CYP11A1 gene in the testes has been characterised. CYP11A1 is located in a region where a QTL influencing boar fat androstenone levels has been detected in a Large White pig population. Clarifying the role of CYP11A1 in boar taint is important because it catalyses the initial step of androstenone synthesis and also of steroid synthesis.

Results

A genome-wide association study located CYP11A1 at approximately 1300 kb upstream from SNP H3GA0021967, defining the centre of the region containing the QTL for androstenone variation. In this study, we partially sequenced the CYP11A1 gene and identified several new single nucleotide polymorphisms (SNP) within it. Characterisation of one a

SUBMITTER: Robic A 

PROVIDER: S-EPMC3098772 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature