Crystal structure of BamD: an essential component of the β-Barrel assembly machinery of gram-negative bacteria.

ABSTRACT: Folding and insertion of integral β-barrel proteins in the outer membrane (OM) is an essential process for Gram-negative bacteria that requires the β-barrel assembly machinery (BAM). Efficient OM protein (OMP) folding and insertion appears to require a consensus C-terminal signal in OMPs characterized by terminal F or W residues. The BAM complex is embedded in the OM and, in Escherichia coli, consists of the β-barrel BamA and four lipoproteins BamBCDE. BamA and BamD are broadly distributed across all species of Gram-negative bacteria, whereas the other components are present in only a subset of species. BamA and BamD are also essential for viability, suggesting that these two proteins constitute the functional core of the bacterial BAM complex. Here, we present the crystal structure of Bam

SUBMITTER: Sandoval CM 

PROVIDER: S-EPMC3098899 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature