Asymmetric enzymatic glycosylation of mitoxantrone.

ABSTRACT: Using a uniquely promiscuous engineered glycosyltransferase (GT) derived from the macrolide-inactivating GT OleD, a single-step asymmetric glucosylation of one 'arm' of the drug mitoxantrone was efficiently achieved in high stereo- and regiospecificity. The synthesis, structural elucidation, and anticancer activity of the corresponding mitoxantrone 4'-β-D-glucoside are described.

SUBMITTER: Zhou M 

PROVIDER: S-EPMC3099400 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature