Synthesis and properties of triazole-linked RNA.

ABSTRACT: RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14°C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed.

SUBMITTER: Mutisya D 

PROVIDER: S-EPMC3099469 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature