A family with Parkinsonism, essential tremor, restless legs syndrome, and depression.

ABSTRACT:

Background

Previous epidemiologic and genetic studies have suggested a link between Parkinson disease (PD), essential tremor (ET), and restless legs syndrome (RLS).

Methods

We describe the clinical, PET, and pathologic characteristics of an extensive kindred from Arkansas with hereditary PD, ET, and RLS. The pedigree contains 138 individuals. Sixty-five family members were examined neurologically up to 3 times from 2004 to 2010. Clinical data were collected from medical records and questionnaires. Genetic studies were performed. Five family members underwent multitracer PET. Two individuals with PD were examined postmortem.

Results

Eleven family members had PD with generally mild and slowly progressive symptoms. Age at onset was between 39 and 74 years (mean 59.1, SD

SUBMITTER: Puschmann A 

PROVIDER: S-EPMC3100088 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature