Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease.

ABSTRACT:

Objective

Clinicopathologic phenotypes of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) often overlap, making discrimination difficult. We performed resting state blood oxygen level-dependent (BOLD) functional connectivity MRI (fcMRI) to determine whether there were differences between AD and DLB.

Methods

Participants (n = 88) enrolled in a longitudinal study of memory and aging underwent 3-T fcMRI. Clinical diagnoses of probable DLB (n = 15) were made according to published criteria. Cognitively normal control participants (n = 38) were selected for the absence of cerebral amyloid burden as imaged with Pittsburgh compound B (PiB). Probable AD cases (n = 35) met published criteria and had appreciable amyloid deposits with PiB imaging. Functional images were coll

SUBMITTER: Galvin JE 

PROVIDER: S-EPMC3100121 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature