Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis.

ABSTRACT:

Objectives

Intracerebral hemorrhage (ICH) is a highly lethal disease of the elderly. Use of statins is increasingly widespread among the elderly, and therefore common in patients who develop ICH. Accumulating data suggests that statins have neuroprotective effects, but their association with ICH outcome has been inconsistent. We therefore performed a meta-analysis of all available evidence, including unpublished data from our own institution, to determine whether statin exposure is protective for patients who develop ICH.

Methods

In our prospectively ascertained cohort, we compared 90-day functional outcome in 238 pre-ICH statin cases and 461 statin-free ICH cases. We then meta-analyzed results from our cohort along with previously published studies using a random effects mo

SUBMITTER: Biffi A 

PROVIDER: S-EPMC3100126 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature