Antibody-mediated neutralization of flaviviruses: a reductionist view.

ABSTRACT: Flaviviruses are a group of ~70 small RNA viruses responsible for significant morbidity and mortality across the globe. Efforts to develop effective vaccines for several clinically important flaviviruses are underway. Antibodies are a significant component of the host's protective response against flavivirus infection with the potential to contribute to immunity via several distinct mechanisms, including an ability to directly neutralize virus infection. Conversely, virus-reactive antibodies have been implicated in the increased risk of severe clinical manifestations following secondary dengue virus infection. In this review, we will discuss recent progress toward understanding the molecular basis of antibody-mediated neutralization of flaviviruses. Neutralization requires engagement of th

SUBMITTER: Dowd KA 

PROVIDER: S-EPMC3100196 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature