Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.

ABSTRACT:

Background

Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into distinct subtypes: Proneural, Neural, Classical and Mesenchymal. The signatures of these different tumor subtypes may reflect the phenotypes of cells giving rise to them. However, the experimental evidence connecting any specific subtype of GBM to particular cells of origin is lacking. In addition, it is unclear how different genetic alterations interact with cells of origin in determining tumor heterogeneity. This issue cannot be addressed by studying end-stage human tumors.

Methodology/principal findings

To address this issue, we used retroviruses to deliver transforming genetic lesions to glial progenitor

SUBMITTER: Lei L 

PROVIDER: S-EPMC3100315 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature