KIF4 regulates midzone length during cytokinesis.

ABSTRACT:

Background

Midzones, also called central spindles, are an array of antiparallel microtubules that form during cytokinesis between the separated chromosomes. Midzones can be considered to be platforms that recruit specific proteins and orchestrate cytokinetic events, such as sister nuclei being kept apart, furrow ingression, and abscission. Despite this important role, many aspects of midzone biology remain unknown, including the dynamic organization of midzone microtubules. Investigating midzone microtubule dynamics has been difficult in part because their plus ends are interdigitated and buried in a dense matrix, making them difficult to observe.

Result

We employed monopolar cytokinesis to reveal that midzone plus ends appear to be nondynamic. We identified the chromokinesi

SUBMITTER: Hu CK 

PROVIDER: S-EPMC3100440 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature