Higher energy expenditure in humans predicts natural mortality.

ABSTRACT:

Context

Higher metabolic rates increase free radical formation, which may accelerate aging and lead to early mortality.

Objective

Our objective was to determine whether higher metabolic rates measured by two different methods predict early natural mortality in humans.

Design

Nondiabetic healthy Pima Indian volunteers (n = 652) were admitted to an inpatient unit for approximately 7 d as part of a longitudinal study of obesity and diabetes risk factors. Vital status of study participants was determined through December 31, 2006. Twenty-four-hour energy expenditure (24EE) was measured in 508 individuals, resting metabolic rate (RMR) was measured in 384 individuals, and 240 underwent both measurements on separate days. Data for 24EE were collected in a respiratory chamber

SUBMITTER: Jumpertz R 

PROVIDER: S-EPMC3100751 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature